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TL;DR: Exin is relocating its wet lab from San Francisco to Manila, Philippines to establish a neuroscience data factory. This new lab model is designed to generate multimodal brain datasets on an ultra-large scale at dramatically lower cost per datapoint. We aim to uncover the conserved manifolds that link neural circuit activity to clinical outcomes, enabling the first generation of predictive models for neurotherapeutic drug discovery.

The traditional lab model vs. AI-driven discovery needs

Neurotherapeutic drug development faces some of the highest attrition rates. Drugs that appear effective in animal or cell models almost invariably fail in human trials. Our discovery models capture too little of the brain’s complexity to predict how interventions will generalize to humans. While animal models have their limitations, we believe the translation gap is driven less by “bad models” and more by our inability to identify which model-specific metrics actually map onto human neurological pathologies and therefore carry predictive validity. High-dimensional neural datasets are collapsed into oversimplified readouts and we treat temporal snapshots of lifelong circuit dynamics as if they were static endpoints. This leaves a fundamental data gap: our models are not grounded in the full complexity of neural systems, so they miss the mark when translated to human biology.

AI offers a way to bridge this gap by revealing the right manifolds i.e. the low-dimensional structure that links multimodal signals across species and timescales to human-relevant outcomes. To do this, however, AI models need to be trained on rich and expansive datasets. These must be longitudinal and multimodal, collected across species, and sufficiently large to discern which features of an animal/cell model truly map onto human clinical biomarkers. Without such scale and diversity in data, even the most sophisticated algorithms will overfit to the wrong patterns and fail to generalize. In other domains, similar breakthroughs (e.g. AlphaFold for protein folding) were enabled by rich datasets and powerful foundation models. But no such foundation models exist for neurotherapeutics yet, because brain data has remained too narrow in scope and magnitude.

The ideal datasets for AI-driven neurotherapeutic discovery need to:

• Include many subjects across different conditions, doses, and tasks to reveal stable, intervention-relevant manifolds.

• Combine neural, behavioral, molecular, and clinical readouts so we can align events across different timescales and levels of analysis.

• Link data from rodents, non-human primates, and humans, enabling joint latent spaces where animal readouts translate to human biomarkers.

• Track subjects over development or disease progression. This lets models learn trajectories on the manifold (e.g. onset, compensation, relapse) and predict how an intervention might correct an individual’s trajectory.

Achieving this level of scale is impossible within the artisanal workflows of today’s academic and biotech labs. It requires an entirely new operational model for data collection.

Reimagining brain data collection: The neuroscience data factory

Enter the concept of a neuroscience data factory. By applying the principles of automation, scale, and rapid iteration used in tech and high-throughput biology, we aim to industrialize in vivo neuroscience research. In practical terms, this means building an infrastructure of automated systems and standardized protocols that run experiments continuously with minimal human intervention.

We’ve already seen precedents for this approach in other areas of drug discovery. Recursion, for example, built an automated in vitro biology platform that runs over two million cell culture experiments per week, yielding one of the largest datasets in pharma. This kind of industrialized, high-throughput experimentation has been hugely valuable in cell biology and chemistry. However, for complex brain disorders we can’t rely on cell cultures alone. The intact mammalian brain – with its circuitry and behaviors – remains our best proxy for the human neural system. The challenge is that running traditional in vivo experiments at scale is extremely expensive and labor-intensive.

So how do we make large-scale in vivo neuroscience experimentation feasible? We can frame the challenge with two simple metrics:

• Number of validated data points ≈ number of rigs × duty cycle × experiment success rate

• Cost per datapoint ≈ total operating expense / number of validated datapoints

The key principles therefore focus on scaling validated data generation and minimizing the cost per datapoint, by engineering every part of the workflow for throughput and reproducibility. Our approach centers on a few core principles:

• Spend every dollar only where it yields more data. We prioritize investment in assays and data-capture capacity over nice-to-have overhead.

• Wherever possible, prioritize experiments with low manual-labour requirements. For example, automated behavioral setups and high-density neural recordings all enable experiments to run around the clock. Automation not only boosts throughput but also standardizes quality. Every rig follows SOPs and quality control checks, ensuring that data are reliable and consistent across runs.

• Implement end-to-end, version-controlled data pipelines from acquisition to analysis. In practice, every step, from initial signal recording, to data preprocessing (e.g. spike sorting or image analysis), to feature extraction, is predefined, logged, and auditable. If an experiment is repeated, the processing of its data will be reproducible and not dependent on ad-hoc decisions. This rigor eliminates a huge source of variability and error, further lowering the “cost” of each usable datapoint.

Why Manila, Philippines?

The decision to base our neuroscience data factory in Manila was driven by the above described principles and some strategic advantages.

• Facility rentals, utilities, and salaries for skilled staff are at a fraction of those in other traditional biotech hubs. This allows us to reinvest into more equipment, more experiments, and further automation, creating a positive feedback loop of scaling.

• The Philippines is a country of over 110 million people with a strong educational emphasis on science and engineering. Many Filipino scientists (including our CSO, Ivan) have trained or worked abroad and are eager to apply their expertise back home on cutting-edge projects.

• Manila is well-connected with proximity to major Asian logistics hubs. We get laboratory supplies, equipment, and reagents shipped quickly because many global vendors have distribution centers in the region. Moreover, the Philippines has strong business and regulatory ties to the US. English is an official language, and regulations and standards are inspired by U.S. norms.

Conclusion

The move of Exin’s wet-lab to Manila and the creation of a neuroscience data factory is going to break the bottlenecks that have stymied progress in neurotherapeutics. By lowering the cost of data and using the savings to raise the scale of data generation, we can move into the era of predictive neurotherapeutic discovery. Our conviction is that this is how we bridge the preclinical → clinical divide and unlock the next generation of treatments for brain disorders that affect millions of patients worldwide.

Neuro‑AI is a bidirectional enterprise: metaphors from machine learning help sharpen our hypotheses about brain function, while biological constraints suggest how to build more efficient artificial systems. Here, we frame cortical computation through the lens of graph neural networks (GNNs): local, energy‑constrained message passing that preserves relational structure under wiring and metabolic budgets. This framing serves both as a neuroscientific hypothesis about why topographies, receptive fields, and distance‑dependent connectivity look the way they do, and as a compact design principle for AI models that generalize better, from less data and at lower energy cost. 

The Graph Neural Network Hypothesis

GNNs are distinguished from classical ANNs by their explicit encoding of relational data through structured message passing across interconnected nodes (Battaglia et al., 2018). Crucially, message passing occurs locally, guided by adjacency relations defined by edges. This structural inductive bias naturally aligns with biological principles governing neuronal connectivity and coding. Neurons in cortical and subcortical structures form densely interconnected graphs. Connectivity decays predictably with spatial distance, reflecting the principle of wiring minimization (Bullmore & Sporns, 2012). Such distance-dependent connectivity ensures that neurons primarily interact with spatially and functionally related neighbors, thus implicitly creating a relational message-passing system reminiscent of modern GNNs.

Cortical Homunculi: Relational Structure in Sensory Coding

A striking illustration of the brain's relational computation emerges from sensory topographies like the cortical homunculus. Penfield and Boldrey (1937) first documented the distorted somatotopic organization of the human somatosensory cortex, where disproportionately large cortical areas represent body parts with higher receptor densities. Rather than a simple reflection of physical size, this cortical layout emphasizes relational proximity: adjacent cortical columns correspond to adjacent body regions, preserving sensory neighborhoods. The cortical homunculus thus exemplifies a graph embedding, where local message passing among neurons preserves sensory adjacency relationships rather than absolute spatial coordinates (Kaas, 1997). Just as GNNs embed input graphs into latent spaces that preserve relational proximity, cortical maps embed body surfaces onto cortical sheets, maintaining local relational integrity.

Receptive Fields and Graph-Based Neural Coding

Similarly, receptive fields in visual and auditory systems exhibit relational coding characteristics. Visual cortical areas (V1, V2, etc.) are organized retinotopically, preserving retinal adjacency relations. Auditory cortical tonotopic maps represent adjacent sound frequencies in neighboring cortical regions (Merzenich & Brugge, 1973). These topographic representations directly parallel GNN embedding procedures, encoding input relationships through adjacency-constrained message passing. Hubel and Wiesel (1962) demonstrated how neurons in primary visual cortex integrate inputs from spatially adjacent receptive fields, akin to local message aggregation in GNN layers. This spatially restricted integration ensures neurons capture relational information intrinsic to visual stimuli, essential for recognizing features like edges, orientations, and ultimately complex objects.

Distance-Dependent Connectivity: A Fundamental Principle

Neuronal wiring adheres to a robust principle: connectivity probability diminishes exponentially with anatomical distance (Markov et al., 2013). This principle not only reduces metabolic and wiring costs but naturally implements relational inductive biases central to GNN computations. Short-range recurrent excitatory and inhibitory connections allow local information integration, reinforcing the relational structure within sensory maps (Douglas & Martin, 2004). Such spatially constrained connectivity mirrors the neighborhood aggregation performed by GNNs, with neurons acting as nodes exchanging signals primarily with topologically adjacent peers. The propagation of neural signals thus implicitly encodes relational information, allowing the brain to efficiently extract structured patterns and generalize across sensory modalities.

Plasticity and Dynamics in Cortical Graphs

While classical GNNs typically operate on static adjacency matrices, cortical relational structures are inherently dynamic due to experience-dependent plasticity. The size and connectivity strength of cortical maps, such as the homunculus, are modulated by sensory experience, notably demonstrated by experiments involving sensory deprivation (Wiesel & Hubel, 1963). Incorporating plasticity mechanisms into GNN frameworks, where adjacency matrices dynamically evolve based on sensory inputs and experience, would thus increase their biological plausibility, providing a richer conceptual framework for cortical function.

Relational priors as an energy budget

If the cortex optimizes for relational preservation, wiring cost acts like an implicit prior. Local, sparse message passing with short‑range recurrence encodes neighborhood structure while minimizing metabolic load. The AI implication is that GNNs with locality constraints and learnable sparsity (e.g., top‑k edges or routing‑by‑need) should improve sample efficiency and energy efficiency on manifold‑structured data such as vision, audio, and sensor graphs.

Development, plasticity, and the stabilization of maps

Topographic maps (retino‑, tono‑, and somatotopy) self‑organize under activity‑dependent rules and then stabilize via pruning and myelination. A GNN view predicts critical‑period dynamics: early, high‑plasticity phases that shape graph topology (which edges exist) followed by lower‑plasticity phases that tune weights (how strongly messages pass). For AI, staged training that first learns adjacency (who communicates) and then learns messages (what is communicated) may reduce overfitting and improve transfer.

Cross‑modal alignment as graph matching

Perception and action rely on aligning partially independent graphs (e.g., visual and somatosensory) into shared relational coordinates. Contrastive or correspondence‑based objectives that match neighborhoods across modalities (rather than raw features) mirror cortico‑cortical integration. In AI, cross‑modal GNN alignment can enhance generalization and robustness to sensor drift.

Neurological disorders as graph errors

From this perspective, we can speculate about neurological disorders in which some of the symptomatology can be metaphorically understood through dysfunctional GNNs. Examples could include amblyopia (early mis‑establishment of retinotopic edges leading to persistent under‑weighting of one input), task‑specific focal dystonia (over‑merging of adjacent somatotopic nodes that blurs fine control), tinnitus (runaway recurrent amplification within tonotopic subgraphs after deafferentation), hemispatial neglect (hub failure in spatial attention networks that breaks long‑range integration), developmental dyslexia (instability in phoneme–grapheme mapping graphs degrading relational consistency), autism spectrum conditions (strong local clustering with reduced long‑range edges limiting global integration), schizophrenia (noisy or mis‑signed messages between associative hubs yielding spurious relational inferences), and temporal lobe epilepsy (hyperexcitable hubs that dominate message flow and trap activity in pathological attractors).

Conclusion

If the brain computes by preserving relational structure through localized, energy‑constrained message passing, then GNN‑like principles offer a hypothesis for a fundamental principle in neural function and a practical blueprint for AI that is more data‑efficient, robust, and frugal. In that spirit, we anticipate therapies that increasingly target connectivity motifs (who talks to whom) rather than only cell types; hardware and software stacks that enforce locality and sparsity to achieve large gains in joules per inference; and two‑stage curricula that learn topology first and messages second to yield stable, transferable representations. Getting the relations right may prove to be the shortest path to both understanding biological intelligence and building better machines.

References

• Battaglia, P. W., et al. (2018). Relational inductive biases, deep learning, and graph networks. arXiv. 

• Bullmore, E., & Sporns, O. (2012). The economy of brain network organization. Nature Reviews Neuroscience.

• Friston, K., Parr, T., & de Vries, B. (2018). The graphical brain: belief propagation and active inference. Network Neuroscience.

• Kaas, J. H. (1997). Topographic maps are fundamental to sensory processing. Brain Research Bulletin.

• Penfield, W., & Boldrey, E. (1937). Somatic motor and sensory representation in the cerebral cortex. Brain.

• Rao, R. P. N., & Ballard, D. H. (1999). Predictive coding in the visual cortex. Nature Neuroscience.

• Markov, N. T., et al. (2013). Cortical high-density counterstream architectures. Science.